A case of mother and child with CANDLE syndrome: Diagnosis and subsequent treatment with baricitinib.
William GuoDaniel LozeauMarcia TonnesenSusan SchuvalAdriana de JesusDevin MillerSara AlehashemiLeonard KristalPublished in: Pediatric dermatology (2024)
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) or proteasome-associated autoinflammatory syndrome is a rare autoinflammatory disorder that typically presents in infancy with characteristic symptoms, including recurrent fever, panniculitis, and progressive lipodystrophy, among other findings. We present a case of mother and child with CANDLE syndrome. The child was eventually started on baricitinib with normalization of rash and systemic findings.