Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies.

Matthew MollSharon M LutzAuyon J GhoshPhuwanat SakornsakolpatCraig P HershTerri H BeatyFrank DudbridgeMartin D TobinMurray A MittlemanEdwin K SilvermanBrian D Hobbs Michael H Cho

Published in: BMJ open respiratory research (2021)

Family history and the PRS provide complementary information for predicting COPD and related outcomes. Future studies can address the impact of obtaining both measures in clinical practice.

Keyphrases

chronic obstructive pulmonary disease
clinical practice
lung function
case control
metabolic syndrome
air pollution
skeletal muscle