Primary central nervous system lymphoma presenting as multiple space-occupying lesions in advanced human immunodeficiency virus infection.
Sara ZafarMaria JavedNeesha RockwoodFarhat KazmiPublished in: SA journal of radiology (2017)
A 31-year-old man presented with seizures and cerebellar symptoms on a background of weight loss and lethargy. He was found to be infected with human immunodeficiency virus (HIV) and following radiological imaging, was commenced on treatment for presumed cerebral toxoplasmosis. Due to a lack of response, both clinically and on interval imaging, a positron-emission tomography-computed tomography and brain biopsy were undertaken, which demonstrated high-grade primary central nervous system lymphoma (PCNSL). Awareness amongst both clinicians and radiologists of the multifarious patterns of intra-cranial involvement in patients with HIV is, therefore, of utmost importance, as the treatment and prognosis of these entities are entirely different.
Keyphrases
- human immunodeficiency virus
- positron emission tomography
- computed tomography
- antiretroviral therapy
- hepatitis c virus
- hiv infected
- hiv positive
- high grade
- hiv aids
- weight loss
- high resolution
- hiv testing
- diffuse large b cell lymphoma
- men who have sex with men
- bariatric surgery
- magnetic resonance
- magnetic resonance imaging
- south africa
- pet ct
- cerebrospinal fluid
- artificial intelligence
- subarachnoid hemorrhage
- pet imaging
- combination therapy
- machine learning
- insulin resistance
- brain injury
- multiple sclerosis
- image quality
- skeletal muscle
- induced pluripotent stem cells