Metal-Free Three-Component Oxyalkynylation of Alkenes.

Yangshan LiRan LuShutao SunLei Liu

Published in: Organic letters (2018)

An unprecedented (NH4)2S2O8 mediated metal-free three-component alkene oxyalkynylation using H2O or alcohol as oxygenation agent is described. Mechanistic studies suggested that the reversed regioselectivity should be dictated by an alkene radical cation intermediate.

Keyphrases

ionic liquid
room temperature
case control
blood flow
alcohol consumption
metal organic framework