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[Association of polymorphisms of genes TCF7L2, FABP2, KCNQ1, ADIPOQ with the prognosis of the development of type 2 diabetes mellitus].

E S Mel'nikovaOksana D RymarA A IvanovaSvetlana V MustafinaMarina ShapkinaM BobakSophia MalyutinaMikhail I VoevodaVladimir N Maksimov
Published in: Terapevticheskii arkhiv (2020)
The rs7903146 polymorphism of theTCF7L2gene confirmed its association with the prognosis of the development of T2D, which indicates the possibility of considering it as a candidate for inclusion in a diabetes risk meter. Variants of risk meters have been developed to assess the prognosis of the development of diabetes mellitus 2 in men and women aged 4569 years during 10 years of follow-up. The association with the prognosis of the development of T2D polymorphisms rs1799883 of theFABP2gene, rs2237892 of theKCNQ1gene and rs6773957 of theADIPOQgene was not found.
Keyphrases
  • copy number
  • genome wide
  • genome wide identification
  • type diabetes
  • gene expression
  • adipose tissue
  • metabolic syndrome
  • transcription factor
  • weight loss
  • genome wide analysis
  • insulin resistance