Emerging use of senolytics and senomorphics against aging and chronic diseases.
Jan MartelDavid M OjciusCheng-Yeu WuHsin-Hsin PengLaurent VoisinJean-Luc PerfettiniYun-Fei KoJohn D YoungPublished in: Medicinal research reviews (2020)
Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.
Keyphrases
- cell cycle arrest
- cell death
- pi k akt
- idiopathic pulmonary fibrosis
- type diabetes
- induced apoptosis
- cardiovascular disease
- signaling pathway
- healthcare
- wound healing
- public health
- mental health
- cell proliferation
- rheumatoid arthritis
- endoplasmic reticulum stress
- dna damage
- oxidative stress
- insulin resistance
- young adults
- weight loss
- squamous cell carcinoma
- skeletal muscle