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Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs.

Hailong LiuBiao HuangShaolong XueKin Pong ULai Ling TsangXiaohu ZhangGang LiXiaohua Jiang
Published in: Stem cell research & therapy (2020)
Altogether, our study indicates the existence of a complex interplay between the mTORC1/p70S6K pathway and the heterochromatin organization during stress-induced MSC senescence, with important implications for the understanding of aging as well as for its prevention and treatment.
Keyphrases
  • stress induced
  • mesenchymal stem cells
  • combination therapy