Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs.
Hailong LiuBiao HuangShaolong XueKin Pong ULai Ling TsangXiaohu ZhangGang LiXiaohua JiangPublished in: Stem cell research & therapy (2020)
Altogether, our study indicates the existence of a complex interplay between the mTORC1/p70S6K pathway and the heterochromatin organization during stress-induced MSC senescence, with important implications for the understanding of aging as well as for its prevention and treatment.