A low MW inhibitor of CD44 dimerization for the treatment of glioblastoma.

Chongwu WangZhaotao WangChen ChenXiaojun FuJi WangXiaowei FeiXiaojing YanRuxiang Xu

Published in: British journal of pharmacology (2020)

Verbascoside suppressed growth of glioblastoma cells by inhibiting CD44 dimerization. Stem cell-like cell properties and tumour cell growth were also suppressed by verbascoside, both in vitro and in vivo. Verbascoside significantly prolonged survival of xenografted mice.

Keyphrases

stem cells
induced apoptosis
cell therapy
signaling pathway
single cell
cell cycle arrest
nk cells
high fat diet induced
oxidative stress
type diabetes
endoplasmic reticulum stress
free survival
cell proliferation
combination therapy
skeletal muscle