Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.

Qi ZhangHe LiXuelan ChenFan GuLanxin ZhangLu ZhangTong ChenQiang ChenWentong Meng Yu WuHong ChangTing LiuChong ChenHongbing Ma Yu Liu

Published in: Blood (2023)

Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. While STRN3-RARA leukemia quickly relapses after ATRA treatment, they can be restrained by cepharanthine.

Keyphrases

liver failure
acute myeloid leukemia
bone marrow
respiratory failure
copy number
genome wide
drug induced
aortic dissection
genome wide identification
hepatitis b virus
replacement therapy
type diabetes
dna methylation
extracorporeal membrane oxygenation