Glycosylated apolipoprotein J in cardiac ischaemia: molecular processing and circulating levels in patients with acute ischaemic events.
Judit CubedoTeresa PadróGemma VilahurFilippo CreaRobert F StoreyJose Luis Lopez SendonJuan-Carlos KaskiAlessandro SionisJordi Sans-RosellóEstefanía Fernández-PeregrinaAlex GallinatLina BadimónPublished in: European heart journal (2021)
These results indicate that ischaemia induces an intracellular accumulation of non-glycosylated ApoJ and a reduction in ApoJ-Glyc secretion. Glycosylated apolipoprotein J circulating levels are reduced very early after ischaemia onset. Its continuous decrease indicates a worsening in the evolution of the cardiac event, likely identifying patients with sustained ischaemia after AMI.