Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain.

Clémence DisdierFares AwaXiaodi ChenSimerdeep K DhillonRobert GalinskyJoanne O DavidsonChristopher A LearLaura BennetAlistair J GunnBarbara S Stonestreet

Published in: Journal of neuroinflammation (2020)

Prolonged exposure to LPS in preterm fetal sheep resulted in decreased vessel density and neurovascular remodeling, suggesting that chronic inflammation adversely affects the neurovascular unit and, therefore, could contribute to long-term impairment of brain development.

Keyphrases

resting state
white matter
inflammatory response
low birth weight
preterm birth
gestational age
oxidative stress
functional connectivity
toll like receptor
cerebral ischemia
preterm infants
lps induced
multiple sclerosis