Inhaled high molecular weight hyaluronan ameliorates respiratory failure in acute COPD exacerbation: a pilot study.

Flavia GaldiClaudio PedoneChristopher A McGeeMargaret GeorgeAnnette B RiceShah S HussainKadambari VijaykumarEvan R BoitetGuillermo J TearneyJohn A McGrathAudrey R BrownSteven M RoweRaffaele A IncalziStavros Garantziotis

Published in: Respiratory research (2021)

Inhaled HMW-HA shortens the duration of respiratory failure and need for non-invasive ventilation in patients with AECOPD. Beneficial effects of HMW-HA on mucociliary clearance and inflammation may account for some of the effects (NCT02674880, www.clinicaltrials.gov ).

Keyphrases

respiratory failure
extracorporeal membrane oxygenation
chronic obstructive pulmonary disease
mechanical ventilation
cystic fibrosis
oxidative stress
lung function
acute respiratory distress syndrome
mouse model
intensive care unit
air pollution
hepatitis b virus