Olaparib and temozolomide in desmoplastic small round cell tumors: a promising combination in vitro and in vivo.

Anke E M van ErpLaurens van HoudtMelissa H S Hillebrandt-RoeffenNiek F H N van BreeUta E FluckeThomas MentzelJanet ShipleyIngrid M E DesarEmmy D G FleurenYvonne M H Versleijen-JonkersWinette T A van der Graaf

Published in: Journal of cancer research and clinical oncology (2020)

We show high PARP1 and SLFN11 expression in DSRCT tumor material and antitumor effects following olaparib and TMZ combination treatment in a preclinical DSRCT model. This suggests that olaparib and TMZ combination treatment could be a potential treatment option for DSRCTs.

Keyphrases

stem cells
dna damage
bone marrow
climate change
long non coding rna
newly diagnosed