Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study.

Mark R Janse van Mantgem Ruben P A van EijkHannelore K van der BurghHarold H G TanHenk-Jan WestenengMichael A van EsJan Herman VeldinkLeonard H van den Berg

Published in: Journal of neurology, neurosurgery, and psychiatry (2020)

This population-based study shows that two-thirds of the patients with ALS have WL at diagnosis, which also occurs independent of dysphagia, and is related to survival. Our results suggest that WL is a multifactorial process that may differ from patient to patient. Gaining further insight in its underlying factors could prove essential for future therapeutic measures.

Keyphrases

amyotrophic lateral sclerosis
weight loss
case report
bariatric surgery
type diabetes
current status
roux en y gastric bypass
metabolic syndrome
skeletal muscle
body mass index
insulin resistance