Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA).
Ivana PetrovicJonathan LoPrestiShireen FatemiAndrew GianoukakisKenneth BurmanCristiane J Gomez-LimaCaroline T NguyenCarole Ann SpencerPublished in: The Journal of clinical endocrinology and metabolism (2024)
1) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. 2) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS and RIA). 3) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.