Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patients.

Anna Lucia TorneselloChiara BottiAlberto MicilloFrancesco LaboniaSergio ArpinoMaria Antonietta IsgròSerena MeolaLuigi RussoErnesta CavalcantiSilvia SaleCarmine NicastroLuigi AtripaldiNoemy StaritaAndrea CerasuoloUlf ReimerPavlo HolenyaLuigi BuonaguroFranco M BuonaguroMaria Lina Tornesello

Published in: Journal of translational medicine (2023)

Overall, our results showed that antibodies elicited by specific linear epitopes of SARS-CoV-2 proteome are age dependent and related to COVID-19 clinical severity. Cross-reaction of antibodies to epitopes of other human coronaviruses was evident in all patients with distinct profiles between children and adult patients. Several SARS-CoV-2 peptides identified in this study are of particular interest for the development of vaccines and diagnostic tests to predict the clinical outcome of SARS-CoV-2 infection.

Keyphrases

sars cov
respiratory syndrome coronavirus
endothelial cells
young adults
coronavirus disease
single cell