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Haploinsufficiency in non-homologous end joining factor 1 induces ovarian dysfunction in humans and mice.

Guoqing LiXi YangLingbo WangYuncheng PanSiyuan ChenLingyue ShangYicheng ZhangYucheng WuZixue ZhouQing ChenXue ZhangLing ZhangYingchen WangJinsong LiLi JinYanhua WuXiaojin ZhangFeng Zhang
Published in: Journal of medical genetics (2021)
Our observations in both humans and mice suggest that NHEJ1 haploinsufficiency is associated with non-syndromic POI, providing novel insights into genetic counselling and clinical prevention of POI.
Keyphrases
  • high fat diet induced
  • dna repair
  • dna damage
  • intellectual disability
  • oxidative stress
  • genome wide
  • gene expression
  • insulin resistance
  • metabolic syndrome
  • autism spectrum disorder
  • hepatitis c virus
  • hiv testing