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One-pot furan synthesis through diethylzinc-mediated coupling reaction between two α-bromocarbonyl compounds.

Ryo HikimaAika TakeshimaTaichi Kano
Published in: Organic & biomolecular chemistry (2023)
Polysubstituted furans were synthesized in one-pot through the Et 2 Zn-mediated coupling reaction between dibromoketones and monobromo carbonyl compounds and the subsequent β-elimination with bromoacetyl bromide. Polysubstituted pyrroles were also prepared in one-pot by addition of primary amines after the coupling reaction.
Keyphrases
  • electron transfer
  • room temperature
  • heavy metals
  • ionic liquid