Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice.

Ivan WeinsantoAlexis Laux-BiehlmannJinane MouheicheTando MadunaFrançois DelalandeVirginie ChavantFlorian GabelPascal DarbonAlexandre CharletPierrick PoisbeauMarc LamshöftAlain Van DorsselaerSarah CianferaniMarie-Odile ParatYannick Goumon

Published in: British journal of pharmacology (2018)

Our data suggests that tolerance to the analgesic effects of morphine is not linked to increased glucuronidation to M3G or to altered global BBB permeability of morphine.

Keyphrases

blood brain barrier
white matter
endothelial cells
type diabetes
machine learning
adipose tissue
spinal cord injury
anti inflammatory
resting state
high fat diet induced
neuropathic pain
insulin resistance
subarachnoid hemorrhage
functional connectivity