Adipose tissue-derived stromal cells' conditioned medium modulates endothelial-mesenchymal transition induced by IL-1β/TGF-β2 but does not restore endothelial function.

Tácia Tavares Aquinas Liguori Gabriel Romero LiguoriLuiz Felipe Pinho MoreiraMartin Conrad Harmsen

Published in: Cell proliferation (2019)

We demonstrated that ASC-CMed reduces IL-1β/TGF-β2-induced EndMT as observed by the loss of mesenchymal markers. The present study supports the anti-fibrotic effects of ASC-CMed through the modulation of the EndMT process.

Keyphrases

adipose tissue
bone marrow
transforming growth factor
stem cells
nlrp inflammasome
high glucose
insulin resistance
high fat diet
type diabetes
oxidative stress