Fe-Doped Polyoxometalate as Acid-Aggregated Nanoplatform for NIR-II Photothermal-Enhanced Chemodynamic Therapy.
Yunhao ShiJiaojiao ZhangHan HuangChangyu CaoJiajia YinWenjing XuWenjun WangXuejiao SongYewei ZhangXiaochen DongPublished in: Advanced healthcare materials (2020)
The combination of reactive oxygen species-involved chemodynamic therapy (CDT) and photothermal therapy (PTT) holds great promise in enhancing anticancer effects. Herein, a multifunctional Fe-doped polyoxometalate (Fe-POM) cluster is fabricated via a simple method. The Fe-POM can not only be utilized as PTT agents to generate a hyperthermia effect for cancer cell killing under near-infrared (NIR) II laser (1060 nm) irradiation, but also can be used as CDT agents to convert endogenous less-reactive H2 O2 into harmful ·OH and simultaneously deplete glutathione for an amplified CDT effect. Notably, the hyperthermia induced by PTT can further enhance the CDT effect, achieving a synergistic PTT/CDT effect. Owing to the self-assembling properties at lowered pH values, the Fe-POM exhibits high tumor accumulation as revealed by photoacoustic imaging. More importantly, Fe-POM enables effective destruction of tumors without inducing noticeable damage to normal tissues under 1060 nm laser irradiation. The work presents a new type of multifunctional agent with high PTT/CDT efficacy, providing promising methods for PTT-enhanced CDT in a NIR-II biowindow.
Keyphrases
- metal organic framework
- photodynamic therapy
- cancer therapy
- drug delivery
- drug release
- fluorescence imaging
- reactive oxygen species
- high resolution
- gene expression
- oxidative stress
- radiation therapy
- highly efficient
- bone marrow
- mass spectrometry
- aqueous solution
- mesenchymal stem cells
- cell therapy
- radiation induced
- fluorescent probe