Histone Lactylation Boosts Reparative Gene Activation Post-Myocardial Infarction.

Naixin WangWeiwei WangXiaoqi WangGe MangJianfeng ChenXiangyu YanZhonghua TongQiannan YangMengdi WangLiangqi ChenPing SunYupeng YangJingxuan CuiMian YangYafei ZhangDongni WangJian WuMaomao ZhangBo Yu

Published in: Circulation research (2022)

Histone lactylation promotes early remote activation of the reparative transcriptional response in monocytes, which is essential for the establishment of immune homeostasis and timely activation of the cardiac repair process post-MI.

Keyphrases

dna methylation
left ventricular
heart failure
gene expression
genome wide
transcription factor
dendritic cells
immune response