The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy.

Shidi WuBertine W HuismanMarion H RietveldRobert RissmannMaarten H VermeerMariette I E van PoelgeestAbdoelwaheb El Ghalbzouri

Published in: Cellular oncology (Dordrecht) (2023)

We successfully developed in vitro 3D vulvar models mimicking both healthy and tumorous conditions which serve as a promising tool for vulvar drug screening programs. Moreover, healthy fibroblasts demonstrate heterogeneity in terms of CAF-activation in VSCC TME which brings insights in the future development of novel CAF-based therapeutic strategies in VSCC.

Keyphrases

sentinel lymph node
public health
single cell
drug induced
adverse drug
emergency department
lymph node
radiation therapy
rectal cancer