Quercetin relieves D-amphetamine-induced manic-like behaviour through activating TREK-1 potassium channels in mice.

Keke RenHaiying LiuBaolin GuoRui LiHonghui MaoQian XueHan YaoShengxi WuZhantao BaiWenting Wang

Published in: British journal of pharmacology (2021)

TREK-1 channels are a novel target for quercetin, by inhibiting PKC. This action could contribute to both the neuroprotective and anti-manic-like effects.

Keyphrases

bipolar disorder
signaling pathway
high glucose
diabetic rats
cerebral ischemia
endothelial cells
metabolic syndrome
type diabetes
adipose tissue
blood brain barrier
subarachnoid hemorrhage