Biophysical phenotyping of circulating immune cells identifies a distinct monocyte-driven signature in systemic sclerosis.

Changes in biophysical properties of circulating immune cells reflect their pathologic activation in SSc and are associated with clinical outcomes. As a high throughput approach that requires minimal preparations, RT-FDC-based biophysical phenotyping of monocytes can serve as a tool for evaluation and risk stratification of patients with SSc.