Recombinant human diamine oxidase prevents hemodynamic effects of continuous histamine infusion in guinea pigs.
Matthias Weiss-TessbachBirgit ReiterElisabeth GludovaczThomas BoehmBernd JilmaMarlene Rager-ReschPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2023)
Prophylactic infusion of rhDAO_mHBM prevents hemodynamic effects in a guinea pig model of continuous histamine infusion. These findings might help in the translation from animals to humans and in the selection of the optimal dosing of rhDAO_mHBM during human histamine challenge studies.