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Chemospecific C3- and C2-Olefinations of Isatins by TfOH-Promoted Tandem Aldol-Grob and Semiacetalization-Grob Fragmentations.
Hongchen Li
Lidong Shan
Chulong Liu
Nan Liu
Yuefei Hu
Yuefei Hu
Published in:
Organic letters (2023)
A novel method for TfOH-promoted chemospecific C3- and C2-olefinations of isatins is developed, which offers the first examples of Grob fragmentation using isatins and amides as substrates.
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