Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer's disease.

Tatsuhiro TeradaJoseph TherriaultMin Su KangMelissa SavardTharick Ali PascoalFiroza LussierCecile TissotYi-Ting WangAndrea BenedetNina Margherita PoltronettiJulie OttoyJaime Frenandez AriasGleb BezginTakashi MatsudairaTomoyasu BunaiTomokazu ObiHideo TsukadaYasuomi OuchiPedro Rosa-Neto

Published in: European journal of neurology (2022)

F]BCPP-EF as an excellent imaging tool to investigate mitochondrial dysfunction in AD.

Keyphrases

cognitive decline
mild cognitive impairment
high resolution
oxidative stress
mass spectrometry