A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus.

Cheng-Shi JiangYan-Qiong GuoSheng YinHua ZhangGui-Hua Tang

Published in: Journal of Asian natural products research (2018)

Chromatographic fractionation of the EtOH extracts of the Traditional Chinese Medicine (TCM) Chloranthus japonicus, has led to the isolation of a new lindenane-type sesquiterpenoid lactone derivative (1). Rosmarylchloranthalactone E (1), which consists of lindenane sesquiterpenoid lactone and rosmarinic acid moieties linked via an ester bridge, was structurally elucidated by 1D and 2D NMR and HRMS data. Compound 1 was a potent phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 0.96 ± 0.04 μM.

Keyphrases

magnetic resonance
high resolution
electronic health record
big data
simultaneous determination
mass spectrometry
machine learning
water soluble