Clinical-grade cryopreserved doxorubicin-loaded platelets: role of cancer cells and platelet extracellular vesicles activation loop.
Yu-Wen WuCheng-Chain HuangChun Austin ChangouLong-Sheng LuHadi GoubranThierry BurnoufPublished in: Journal of biomedical science (2020)
Cryopreserved DOX-loaded PLT can be prepared under clinically compliant conditions preserving the membrane functionality for anti-cancer therapy. These findings open perspectives for translational applications of PLT-based drug delivery systems.