Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11).
Sridharan GururanganElizabeth ReapRobert SchmittlingMehmet KocakRenee ReynoldsGerald GrantArzu Onar-ThomasPatricia BaxterIan F PollackPeter PhillipsJames BoyettMaryam FouladiDuane MitchellPublished in: Cancer immunology, immunotherapy : CII (2017)
Our results demonstrate that patients with MBL and PFT exhibit overall reduced CD4+ T cell counts at diagnosis but not an elevated proportion of Tregs. Standard treatment exacerbates lymphopenia in those with MBL while enriching for immunosuppressive Tregs over time.