Mcam stabilizes luminal progenitor breast cancer phenotypes via Ck2 control and Src/Akt/Stat3 attenuation.

Ozlen Balcioglu Brooke L Gates David W Freeman Berhane M Hagos Elnaz Mirzaei MehrabadDavid Ayala-TalaveraBenjamin T Spike

Published in: bioRxiv : the preprint server for biology (2024)

Mcam is expressed by diverse breast cancer subtypes.Mcam regulates breast cancer cell state plasticity.Mcam maintains the mammary luminal progenitor state.Mcam attenuates Stat activity.Mcam dictates Ck2 substrate utilization.

Keyphrases

cell proliferation
signaling pathway
protein kinase
young adults
cell fate