Ketamine decreases cell viability of bone explants and impairs bone healing in rats.

Dénes B HorváthyPéter SzántóBence MarschallMarcell BagóMárton CseryIstván HornyákAttila DorosZsombor Lacza

Published in: Journal of orthopaedic surgery and research (2020)

We conclude that multiple ketamine administration was responsible for the diminished regenerative potential of bone tissue in the present experimental setup. For this reason, we suggest that ketamine anesthesia should be avoided in studies investigating bone regeneration.

Keyphrases

bone regeneration
bone mineral density
pain management
stem cells
soft tissue
bone loss
mesenchymal stem cells
postmenopausal women
case control