Novel hypoxia-targeting Pt(iv) prodrugs.

Published in: Chemical communications (Cambridge, England) (2018)

Novel Pt(iv) prodrugs targeting hypoxia inducible factor HIF-1α were prepared for evaluating their antitumor activity on hypoxic cancer cells for the first time. The resulting Pt(iv) prodrug exhibited effective inhibition on tumor growth in the HCT-116 xenograft mouse model with low toxicity in vivo.

Keyphrases

cancer therapy
mouse model
endothelial cells
oxidative stress
drug delivery
cell death