Amphipathic poly-β-peptides for intracellular protein delivery.

Qianyi RenQi ChenLanfang RenChuntao CaoRunhui Liu Yiyun Cheng

Published in: Chemical communications (Cambridge, England) (2022)

A series of amphipathic poly-β-peptides are designed for intracellular protein delivery. The poly-β-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.

Keyphrases

amino acid
protein protein
induced apoptosis
binding protein
reactive oxygen species
ionic liquid
endoplasmic reticulum stress