Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence.

Jonathan D BellAlexander H HarkissDavid NobisEilidh MalcolmAstrid KnuhtsenChristopher R Wellaway Andrew G Jamieson Steven W Magennis Andrew Sutherland

Published in: Chemical communications (Cambridge, England) (2020)

The synthesis and photophysical properties of a new class of α-amino acid bearing a rigid pyrazoloquinazoline chromophore are described. Confromational constraint of the amino acid side-chains resulted in high emission quantum yields, while the demonstration of two-photon-induced fluorescence via near-IR excitation signifies their potential for sensitive bioimaging applications.

Keyphrases

amino acid
energy transfer
high glucose
living cells
diabetic rats
single molecule
drug induced
fluorescent probe
molecular dynamics
endothelial cells