Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death.
Dahiana M GalloWendy FitzgeraldRoberto RomeroNardhy Gomez-LopezDereje W GudichaNándor Gábor ThanMariachiara BoscoTinnakorn ChaiworapongsaEunjung JungArun MeyyazhaganManaphat SuksaiFrancesca GotschOffer ErezAdi L TarcaLeonid MargolisPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2023)
Pregnant women with fetal death have different concentrations of 19 proteins in the EV and soluble fractions compared to controls, and the direction of changes in concentration was similar between fractions. The combination of EV and soluble protein concentrations revealed three different clusters of fetal death cases with distinct clinical and placental histopathological characteristics.