A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis.

Yao LiuFanzheng MengJiabei WangMingyang LiuGuangchao YangRuipeng SongTongsen ZhengYingjian LiangShugeng ZhangDalong YinJizhou WangShangha PanBo SunJihua HanJing SunYaliang LanYan WangXirui LiuMingxi ZhuYifeng CuiBo ZhangDehai WuShuhang LiangYufeng LiuXuan SongZhaoyang LuMin LiLianxin Liu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

We demonstrated the prognostic value of OGDHL, miR-214, and TWIST1 in pancreatic cancer, and elucidated a novel pathway in OGDHL-regulated inhibition of pancreatic cancer tumorigenesis and metastasis. These findings may lead to new targeted therapy for pancreatic cancer through regulating OGDHL, miR-214, and TWIST1.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
epithelial mesenchymal transition
transcription factor
cancer therapy