Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence.

Gautham RameshShubhankar DasBola Sadashiva Satish Rao

Published in: The Journal of pharmacy and pharmacology (2020)

The study expands the understanding of the pharmacological properties of Berberine and its applicability as a radiosensitizer towards treating liver cancer.

Keyphrases

cell cycle arrest
cell death
endothelial cells
pi k akt
signaling pathway
oxidative stress
dna damage
induced apoptosis
induced pluripotent stem cells
stress induced