Identification of generic and pathogen-specific cord blood monocyte transcriptomes reveals a largely conserved response in preterm and term newborn infants.
Emma De JongDavid G HancockJulie HibbertChristine WellsPeter RichmondKaren SimmerDavid BurgnerTobias StrunkAndrew J CurriePublished in: Journal of molecular medicine (Berlin, Germany) (2017)
E. coli and S. epidermidis elicit common transcriptional changes in cord monocytes. The common transcriptional response is mediated by TLR/NF-κB/TREM-1 signalling. IFN-genes are differentially regulated by E. coli and S. epidermidis in monocytes. These responses are largely unaffected by GA or exposure to chorioamnionitis.
Keyphrases
- cord blood
- dendritic cells
- transcription factor
- escherichia coli
- biofilm formation
- immune response
- gene expression
- preterm infants
- toll like receptor
- gestational age
- inflammatory response
- bioinformatics analysis
- pet ct
- nuclear factor
- signaling pathway
- candida albicans
- oxidative stress
- genome wide
- low birth weight
- lps induced
- endothelial cells
- preterm birth
- single cell
- dna methylation
- pi k akt
- pseudomonas aeruginosa
- cystic fibrosis
- cell proliferation
- genome wide identification