AgNPs/nGOx/Apra nanocomposites for synergistic antimicrobial therapy and scarless skin recovery.
Ming ZhaoMingqing ZhouPeng GaoXueyun ZhengWen YuZhenyuan WangJingchao LiJiaheng ZhangPublished in: Journal of materials chemistry. B (2022)
The misuse of antimicrobials has caused a remarkable increase of antibiotic-resistant bacteria. Developing novel antimicrobial agents with high activity and low rates of resistance development is in great demand yet challenging. In this context, we developed a novel cascaded AgNPs/nGOx/Apra nanocomposite for combinational antimicrobial therapy. Glucose oxidase nanocapsules (nGOx) in the nanocomposites can convert tissue glucose into H 2 O 2 , which in turn accelerates the erosion of AgNPs into Ag + , giving rise to a synergistic antibiotic/starving-like/metal ion therapeutic effect. An in vitro antimicrobial study of the nanocomposites demonstrated rapid bacterial killing, significant bacterial growth inhibition and broad antimicrobial spectra at a low antibiotic dose. More importantly, topical and microneedle-assisted deliveries of the nanocomposites resulted in rapid scarless skin recovery in both rabbit and mouse models. This nanocomposite platform opens up a new avenue for research and clinical applications to battle against microbial infections and reduce antibiotic-resistant rates.
Keyphrases
- reduced graphene oxide
- staphylococcus aureus
- carbon nanotubes
- visible light
- quantum dots
- wound healing
- silver nanoparticles
- gold nanoparticles
- high throughput
- type diabetes
- metabolic syndrome
- skeletal muscle
- mass spectrometry
- blood pressure
- mesenchymal stem cells
- fluorescent probe
- weight loss
- loop mediated isothermal amplification
- density functional theory