Long-term non-invasive ventilation for COPD patients following an exacerbation with acute hypercapnic respiratory failure: a randomized controlled trial.
Caroline HedsundKasper Linde AnkjærgaardTine Peick SonnePhilip TønnesenEjvind Frausing HansenHelle Frost AndreassenRonan Martin Griffin BergJens-Ulrik Stæhr JensenJon Torgny WilckePublished in: European clinical respiratory journal (2023)
The risk of the primary outcome, time to readmission with AHRF or death within 12 months was numerically smaller in the LT-NIV group, however, did not reach significance. Nevertheless, several secondary outcome analyses like risk of AHRF, number of episodes of AHRF and exacerbations were all significantly reduced in favour of high-pressure LT-NIV, especially in patients with frequent AHRF.
Keyphrases
- respiratory failure
- extracorporeal membrane oxygenation
- chronic obstructive pulmonary disease
- mechanical ventilation
- end stage renal disease
- ejection fraction
- chronic kidney disease
- acute respiratory distress syndrome
- newly diagnosed
- cystic fibrosis
- prognostic factors
- lung function
- peritoneal dialysis
- patient reported