Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers.

I Muñoz-CoboM M ErburuC ZwergelR CirilliA MaiS ValenteE PuertaRosa M Tordera

Published in: Psychopharmacology (2018)

This study supports the validity of the SH-SY5Y model for studying epigenetic changes linked to synaptic plasticity induced by antidepressants as well as the effect of selective HDAC inhibitors. Particularly, nucleocytoplasmic export of HDAC5 and SIRT2 downregulation mediated by antidepressants could enhance synaptic plasticity markers leading to antidepressant action.

Keyphrases

ischemia reperfusion injury
major depressive disorder
histone deacetylase
oxidative stress
dna methylation
bipolar disorder
gene expression
cell proliferation
signaling pathway