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Neuroprotective Effects of Curcumin-Loaded Emulsomes in a Laser Axotomy-Induced CNS Injury Model.

Elif Nur YilmazSadık BayGurkan OzturkMehmet Hikmet Ucisik
Published in: International journal of nanomedicine (2020)
The established laser-axotomy model was proven as a reliable methodology to study neurodegenerative models ex vivo. CurcuEmulsomes delivered curcumin to primary hippocampal neurons successfully. Treated with CurcuEmulsomes, injured hippocampal neurons benefit from the neuroprotective effects of curcumin, exhibiting a higher survival rate and increased anti-apoptotic marker levels.
Keyphrases
  • cerebral ischemia
  • spinal cord
  • cell death
  • drug delivery
  • blood brain barrier
  • high glucose
  • high speed
  • cancer therapy
  • oxidative stress
  • spinal cord injury
  • temporal lobe epilepsy