Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis.

Urinary exosomal miR-146a levels are correlated with lupus activity, proteinuria and histological features, discriminating patients with LN and being a good baseline marker of SLE flares. We have identified a relevant biological miR-146a-TRAF6 axis association in LN renal fibrosis progression.