A novel adiponectin receptor agonist (AdipoAI) ameliorates type 2 diabetes-associated periodontitis by enhancing autophagy in osteoclasts.

Xingwen WuYang SunRenjie CuiWei QiuJin ZhangZhekai HuWei BiFei YangDuan MaThomas Van DykeQisheng TuYoucheng YuJake Chen

Published in: Journal of periodontal research (2022)

Our results demonstrate that AdipoAI ameliorates the severity of T2D-associated periodontitis by enhancing autophagy in osteoclasts at lower doses than AdipoRon without demonstrable side effects. Thus, AdipoAI has pharmaceutical potential for treating diabetes-associated periodontal disease.

Keyphrases

type diabetes
cell death
glycemic control
endoplasmic reticulum stress
cardiovascular disease
signaling pathway
oxidative stress
insulin resistance
bone loss
mouse model
metabolic syndrome
adipose tissue
skeletal muscle