Platelet-leucocyte aggregation is augmented in cirrhosis and further increased by platelet transfusion.

Sidsel StøyV C PatelJ P SturgeonG K Manakkat VijayJ P LuyendykW BernalDebbie Lindsay Shawcross

Published in: Alimentary pharmacology & therapeutics (2018)

Cirrhotic patients have activated circulating platelet-complexed leucocytes with increased platelet-monocyte aggregation following elective platelet transfusion. Elective platelet transfusion might therefore exacerbate immune dysfunction in cirrhosis.

Keyphrases

cardiac surgery
patients undergoing
newly diagnosed
ejection fraction
sickle cell disease
acute kidney injury
prognostic factors