Effects of fiber intake on intestinal pH, transit, and predicted oral mesalamine delivery in patients with ulcerative colitis.
Chu Kion YaoRebecca E BurgellKirstin M TaylorMark G WardAntony B FriedmanJacqueline S BarrettJane G MuirPeter R GibsonPublished in: Journal of gastroenterology and hepatology (2020)
Patients with quiescent UC have abnormalities in intestinal pH and transit in response to acute changes in fermentable fiber intake. These have potentially detrimental effects on predicted luminal release patterns of pH-dependent 5-aminosalicylic acid release systems.