Intermediate monocytes correlate with CXCR3+ Th17 cells but not with bone characteristics in untreated early rheumatoid arthritis.

Christina Drevinge Julia M SchefflerCatalin Koro-ArvidssonDaniel SundhHans CarlstenInger GjertssonCatharina LindholmMattias LorentzonAnna RudinAnna-Karin Hultgård EkwallUlrika Islander

Published in: PloS one (2021)

Our findings suggest that in early RA, the intermediate monocytes do not correlate with bone characteristics, despite positive correlation with circulating CXCR3+ Th17 cells. Future longitudinal studies in patients with longer disease duration are required to fully explore the potential of intermediate monocytes to drive bone loss in RA.

Keyphrases

bone loss
rheumatoid arthritis
induced apoptosis
cell cycle arrest
disease activity
dendritic cells
peripheral blood
bone mineral density
interstitial lung disease
signaling pathway
risk assessment
current status
climate change
bone regeneration
human health
systemic sclerosis