Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury.

Kojiro TeradaMasanori SasakiHiroshi NagahamaYuko Kataoka-SasakiShinichi OkaRyo UkaiTakahiro YokoyamaYusuke IizukaTakuro SakaiShinobu FukumuraTakeshi TsugawaJeffery D KocsisOsamu Honmou

Published in: Pediatric research (2023)

Intravenous infusion of MSCs improved neurological function in rats with perinatal brain injury, including motor, sensorimotor, cognitive, spatial, and learning memory. Infused MSCs increased residual (non-ischemic) tissue volume, number of neuronal cells, GABAergic cells, and cortical synapses in the contralesional (right) hemisphere. Intravenous administration of MSC might be suitable for the treatment of perinatal brain injury.

Keyphrases

brain injury
cerebral ischemia
mesenchymal stem cells
subarachnoid hemorrhage
induced apoptosis
cell cycle arrest
umbilical cord
pregnant women
high dose
low dose
oxidative stress
working memory
signaling pathway
cell death
ischemia reperfusion injury